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Complex Regional Pain Syndrome


Clinics: Barnsley, Blackpool, Cannock, Leeds, Liverpool, Manchester and Teesside

Therapy Area: Complex Regional Pain Syndrome

Gender and Age: Male and Female aged 18 and over


MAC Clinical Research is currently running a trial to test a new treatment for complex regional pain syndrome (CRPS).

CRPS is a poorly understood condition in which a person experiences persistent severe and debilitating pain.

The treatment being tested is called neridronic acid and will be administered as an intravenous infusion. It belongs to a family of drugs called bisphosphonates which have been used to treat a variety of diseases for the past 40 years.

The purpose of this clinical trial is to further evaluate whether neridronic acid is effective in reducing pain in patients with CRPS. In addition, this trial will investigate the safety of neridronic acid in patients with CRPS and its effect on other symptoms of the condition. There will be between 13 and 17 visits to one of our clinics over a period of 14 months.

Reimbursement: Travel expenses will be reimbursed, or transport can be provided.


Key Inclusion Criteria*

  • Diagnosis of CRPS within the last two years

  • Must be on a stable CRPS treatment for at least 1 month before starting the trial

Key Exclusion Criteria*

  • Tooth extraction or other invasive dental procedure within 3 months

  • Kidney disease or kidney failure, vitamin D or calcium deficiency, or any severe medical condition including severe depression or other mood disorder

  • Participation in another investigational drug trial within 3 months

Other eligibility criteria will apply. Please contact MAC for more information.

Any other information:

Eligible patients will receive a comprehensive health screen and study participation will be in collaboration with the patient’s treating physician.